Frankfurt, a major convention destination, is the heart of the Rhine-Main Region and one of Europe's most dynamic business centers. Many companies are based at this key node in the international travel and transportation network. Frankfurt Airport is an important air hub.Financially, the region is home to countless banks, the European Central Bank, Deutsche Bundesbank, and Germany's largest, most important stock exchange. The region also has a deep, broad manufacturing base. The chemical and pharmaceutical industries have a strong presence in the region, as do automotive suppliers and high-tech production, sales and service companies.