France’s third largest city, Lyon offers a vibrant mix of art, history, sophisticated shopping and nightlife, with glut of gourmet restaurants that have earned it the label of gastronomic capital. Lyon, France's most business-friendly city. By choosing to set up or develop your business in Lyon, you are investing in one of Europe's most attractive métropoles; it is a competitive destination that is open to the world. Each year, Lyon attracts ever more companies.